Treatment of hypophosphataemic rickets in childhood is best done by a specialist centre. It not only involves medical treatment but also may need input from occupational therapy, physiotherapy, orthopaedic surgeons and ideally all of these working together.
Medical treatment traditionally has involved giving phosphate supplements multiple times a day. This is to allow enough phosphate in the body for the bones to heal and mineralise. Because the underlying renal phosphate wasting is not addressed, the oral phosphate supplements do not maintain normal blood phosphate levels for very long. Phosphate supplements should not be taken with calcium containing products as this can cause the phosphate and calcium to precipitate and not be absorbed. Along side phosphate supplements, active vitamin D is also given. The high levels of the hormone FGF23 prevents 25 hydroxyvitamin D (25OHD) from being converted into the active form 1,25 OHD. So supplements of 1,alphacalcidol or calcitriol is given.